COULD THE FDA-APPROVED ANTI-HIV PR INHIBITORS BE PROMISING ANTICANCER AGENTS? AN ANSWER FROM ENHANCED DOCKING APPROACH AND MOLECULAR DYNAMICS ANALYSES

Olayide A Arodola, Mahmoud ES SolimanMolecular Modelling and Drug Design Lab, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South AfricaAbstract: Based on experimental data, the anticancer activity of nelfinavir (NFV), a US Food and Drug Administration (FDA)-approved HIV-1 protease inhibitor (PI), was reported.Ne

Remote sensing Stoneware Jug image (RSI) target detection methods based on traditional multiscale feature fusion (MSFF) have achieved great success.However, the traditional MSFF method significantly increases the computational cost during model training and inference, and the simple fusion operation may lead to the semantic confusion of the feature

Thraustochytrids are cosmopolitan osmotrophic or heterotrophic microorganisms that are considered as important decomposers Stoneware Jug in coastal ecosystems.However, because of a lack of estimation method for each genus or systematic group of them, relatively little is known about their ecology in situ.Previously, we reported two distinct types o

The article is devoted to the problem of decentralization of urban self-government in Russia in the XIX - early XXI centuries.Both the practical experience of functioning of intra-urban municipalities (small urban units), and the level of theoretical understanding of the problems of decentralization in different periods of national history are anal

The technical development has significant Collagen Protein effects on the mediator Alcinmatugrave, and TV originated mainly based on technical, with the development and the continuation of these technologies and the enormous impact on the level of the television picture, initially dramas in recent times approaching in the aesthetic composition of t